ADME Senior Scientist

Major Responsibilities：

• Design and implement aggressive, innovative preclinical ADME plans for drug discovery projects.
• As a subject matter expert, work with Drug Disposition colleagues, project teams, and external experts to
develop a strategy for identifying and solving issues in your area of expertise.
• Integrate in vitro, in vivo, and in silico ADME data with discovery biology and medicinal chemistry to define
• Structure activity relationships to drug design strategies and help optimize drug properties.
• Interact across groups, including other departments, regulatory agencies, and functional groups within drug
disposition.
• Responsible for the design, oversight, interpretation, and reporting of preclinical study results.
• Design/execution of preclinical PK/PD studies.
• Lead internal and collaborative research to increase mechanistic understanding of clearance pathways
and/or drug distribution and improve translatability of preclinical models.
• Prepare preclinical data packages and regulatory submissions to enable clinical studies.

Requirement：

• Ph.D. degree in Drug Metabolism, Pharmacokinetics, or Pharmaceutics, or an advanced degree in a related
science with extensive training in the field of drug metabolism and disposition.
• At least 4 years of direct experience in drug discovery.
• Excellent verbal and written communication skills, with fluency in English and Mandarin.
• Strong background in one or more of the following: pharmacokinetics, PBPK modeling, transporters, or drug
metabolism. 